Studies on Benzoheterocyclic Compounds. I

Abstract

Fusion of anthranilamide (VII) with urea or thiourea respectively gave 3-aryl-2, 4-(1H, 3H)-quinazolinedione (I) and 3-aryl-2-thio-2, 4 (1H, 3H)-quinazolinedione (II). 3-Aryl-2, 3-dihydro-4(1H)-quinazolinone (III) was obtained from VII and formaldehyde (cf. Chart 1 and Table I). Central-inhibiting action of the 25 compounds thus obtained was tested and those exhibiting a comparatively strong activity are listed in Tables II, III, and IV.