Resistance Induced by Vaccinia Virus to Pertussis Infection in Mice

Abstract

Summary Mice were protected against infection following intracerebral inoculation of H. pertussis by a prior intracerebral injection of a suitable dose of commercial smallpox vaccine, or of a testicular or a neurotropic strain of vaccinia virus. Evidence was obtained that smallpox vaccine interferes with the development of fatal vaccinial infection in mice induced by a neurotropic strain.