Enantioselective Rhodium‐Catalyzed Addition of Arylboronic Acids to Trifluoromethyl Ketones

Abstract

Abstract A new C 2 ‐symmetrical, chiral bisphosphorus ligand proved to be efficient for the rhodium‐catalyzed nucleophilic addition of arylboronic acids to trifluoromethyl ketones, providing a series of chiral trifluoromethyl‐substituted tertiary alcohols in high yields (up to 93%) and excellent enantioselectivities (>99%).