Tunable 3D Plasmonic Cavity Nanosensors for Surface-Enhanced Raman Spectroscopy with Sub-femtomolar Limit of Detection

Abstract

Metallic nanohole arrays (NHAs) with a high hole density have emerged with potential applications for surface-enhanced Raman spectroscopy (SERS) including the detection of analytes at ultralow concentrations. However, these NHA structures generally yield weak localized surface plasmon resonance (LSPR), which is a prerequisite for SERS measurements. In this work, a compact three-dimensional (3D) tunable plasmonic cavity with extraordinary optical transmission properties serves as a molecular sensor with sub-femtomolar detection. The 3D nanosensor consists of a gold film containing an NHA with an underlying cavity and a gold nanocone array at the bottom of the cavity. These nanosensors provide remarkable surface plasmon polariton (SPP) and LSPR coupling, resulting in a significantly improved detection performance. The plasmonic tunability is evaluated both experimentally and theoretically. A SERS limit of detection of 10 –16 M for 4-nitrothiophenol is obtained along with distribution mapping of the molecule on the 3D plasmonic nanosensor. This results in an improved SERS enhancement factor of 10 7 obtained from a femtoliter plasmonic cavity volume. The tunability of these sensors can give rise to a potential opportunity for use in optical trapping while providing SERS sensing of a molecule of interest.