Induction of Angiogenesis and Modulation of Vascular Endothelial Growth Factor Receptor-2 by Simvastatin After Traumatic Brain Injury

Abstract

Simvastatin augments TBI-induced angiogenesis in the lesion boundary zone and hippocampus and improves functional recovery. Simvastatin also promotes angiogenesis in vitro. These beneficial effects on angiogenesis may be related to simvastatin-induced activation of the VEGFR-2/Akt/endothelial nitric oxide synthase signaling pathway.