Coinheritance of α- and β-Spectrin Gene Mutations in a Case of Hereditary Elliptocytosis

Abstract

To the Editor: Many mutations in the α- and β-spectrin genes are known to be associated with hereditary elliptocytosis (HE). Spectrin abnormalities are detected as abnormal peptides after limited trypsin digestion of spectrin (Sp).[1][1] We had an opportunity to study a Filipino family living in