The Liver as the Site of Carnitine Biosynthesis in Sheep with Alloxan-induced Diabetes

Abstract

The total acid-soluble carnitine concentration in the livers of three sheep increased 20-fold, to 4530 nmoljg wet weight, 10-14 days after induction of the diabetic state by alloxan. There was a threefold increase in the total carnitine concentration of the kidney cortex and no significant change in that of heart or skeletal muscle (M. biceps femoris).