Evaluation of the Cytosorb™ Hemoadsorptive Column in a PIG Model of Severe Smoke and Burn Injury

Abstract

In a porcine model of smoke and burn injury, hemoadsorption using the CytoSorb cartridge did not result in significant systemic or pulmonary reductions in the measured cytokines or myoglobin despite efficient transmembrane reductions. Further investigations are needed to optimize the efficiency of mediator clearance to affect both circulating levels and clinically relevant outcomes.