Concepedia

Publication | Open Access

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

DOIFull Paper Access

128

Citations

35

References

2016

Year

Vera Miranda‐Gonçalves, Sara Granja, Olga Martinho, Mrinalini Honavar, Marta Pojo, Bruno M. Costa, Manuel Melo Pires, Célia Pinheiro, Michelle Cordeiro, Gil Bebiano,
Oncotarget

Abstract

Hypoxia-induced MCT1 supports GBM glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness. Therefore, MCT1 constitutes a promising therapeutic target in GBM.

References

YearCitations

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