Endometrial hyperplasia. Clinico-pathological considerations of a prospective randomised study after abrasio only or high-dose gestagen treatment. Results of 2 years follow-up of 292 patients.

Abstract

Endometrial hyperplasia has since long been proposed to be a predecessor to endometrial carcinoma. In this prospective randomised study one group was treated with abrasio only at regular intervals to follow the natural course. In this group 96/176 were normalised after a 2 year follow-up and 3 patients developed cancer. The frequency of normalised patients after abrasio only (55%) resembles that of cyclic low-dose gestagen treatment. In the other patient group treated with Medroxy progesterone acetate 500 mg i.m. twice weekly for 3 months and then followed for 2 years, 86/89 normalised and none developed cancer.