Chemoprophylaxis of trypanosomiasis, due to Trypanosoma (Nannomonas) congolense, in rabbits using a slow release device containing homidium bromide.

Abstract

The prophylactic activity of a subcutaneously implanted slow release device, containing homidium bromide, was assessed in rabbits, challenged with different stocks of T. congolense, and compared with the classical treatment of 1 mg homidium bromide/kg b.w. intramuscularly. The prophylactic activity of the intramuscular injection was less than a month, while the slow release device protected the rabbits against seven challenges with T. congolense during a period of more than 300 days.