Concepedia

Publication | Closed Access

Research on the Vertical Transmission of Hepatitis C Gene from Father-to-child via Human Sperm

DOI

10

Citations

0

References

2016

Year

Mingfu Ma, Yijian Zhu, Dian Wang, Zhiwei Hou, Jihua Huang, Danyan Zhang, Qing-Dong Xie, Ling Wan, Letian Zhao, Lianbing Li,
Clinical Laboratory

Abstract

The recombinant plasmid pIRES2-EGFP-HCV C was successfully constructed. The HCV C gene was able to pass through the sperm membrane and integrate into the sperm genome. Human sperm carrying the HCV C gene was able to achieve normal fertilization. The replication of the sperm-mediated HCV C gene was synchronized with that of the host genome. Our results provide direct evidence for vertical transmission of the HCV C gene from father-to-child via human sperm.