PubMed · 1978 · 17 citations · 0 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyOncology PharmacotherapyAdverse Effects Of ChemotherapyChemotherapy Drug AdministrationHematologic ToxicityImmune-related Adverse EventsMedication Side Effect ManagementToxicity ManagementDose-limiting Hematologic ToxicityDrug-induced Hematologic ToxicityMetastatic Carcinoma To The BreastSide Effect ProfileTherapeutic Toxicity
Aminoglutethimide is an investigational agent of proven benefit in the treatment of metastatic breast carcinoma. We report herein a case of aminoglutethimide-induced pancytopenia complicated by bleeding and gram-negative septicemia. Severe pancytopenia is a rare but important side effect of this new drug and is rapidly reversible when the agent is withdrawn.