MedicineImmunologyOphthalmologyInflammationOcular ImmunologyOcular PharmacologyImmunopathology Of The EyeImmunosuppressionOcular InflammationTopical Ophthalmic MedicationsUveal DiseaseUveal ImmunologyAcute Inflammatory ResponseAcute UveitisImmune-mediated InflammationImmune-mediated UveitisTopical Anti-inflammatory TherapyTopical ApplicationTopical Medication AdministrationUveitis Pharmacotherapy
The experimental model of immunogenic uveitis induced by intraocular injection of human serum albumin in rabbits was inhibited by the topical application of cyclosporin A. The acute nonspecific inflammatory response that immediately follows intravitreous injection was not affected. However, the severe panuveitis that develops during the second week was markedly reduced. The safety and efficacy of topically applied cyclosporin A in this model of uveitis suggests that topical administration of this antigen-nonspecific immunosuppressor may be an effective route of therapy for certain immune-mediated forms of uveitis.