PharmacyPharmacokineticsPharmacologyChemotherapyDrug MetabolismPharmacokinetics Of Anticancer AgentsAlkylating AgentsDrug DispositionMetabolism Of Anticancer AgentsOncology PharmacologyPharmacokinetics Of Anticancer DrugsAlkylating Agent TherapyMetabolite PharmacokineticsPharmacokinetic Parameters
Alkylating agents have been used for over 30 years in the treatment of malignant disease. Because of their very reactive nature, studies of their intermediate metabolism have been difficult. However, this is now possible with modern analytical techniques. Further understanding of their metabolism and pharmacokinetics should lead to a more rational use in the clinic.