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Association between HLA-expression and infiltration of immune cells in cervical carcinoma.

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References

1993

Year

Carina G. J. M. Hilders, J. G. A. Houbiers, Hedda H. van Ravenswaay Claasen, R.W. Veldhuizen, G.J. Fleuren
PubMed

Abstract

Our observations provide in situ immunomorphologic evidence that in cervical carcinoma, de novo expression of HLA class II antigens on the tumor cells resulted in an increase of tumor-infiltrating immune cells. In addition, the tumor-infiltrating CD8+ T lymphocytes correlated with monomorphic HLA class I expression on the tumor cells, which stresses the existence of a HLA-restricted immune response of T lymphocytes in cervical carcinoma. These findings might have implications for the biologic behavior of this disease and have to be taken into account in strategies concerning immunotherapy of cervical carcinoma.