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Intra-arterial prostacyclin compared to Praxilene in the management of severe lower limb ischaemia: a double blind trial.
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1987
Year
Pain MedicinePharmacotherapySurgeryIntra-arterial ProstacyclinOrthopaedic SurgeryThrombosisHematologyVascular SurgeryPain ManagementAtherosclerosisHealth SciencesPostoperative Pain ManagementProstacyclin InfusionPeripheral Artery DiseasePeripheral Vascular DiseaseDouble Blind StudyCardiovascular DiseaseDouble Blind TrialMajor Limb AmputationMedicineAnticoagulantAnesthesiology
The effectiveness of a 72 h. intra-arterial prostacyclin infusion has been compared to that of naftidrofuryl oxalate (Praxilene) in a double blind study of 29 patients with ischaemic rest pain in 30 legs. Long-term relief of symptoms was achieved in 14 legs (47%) and major limb amputation avoided in 18 (60%). No significant difference was demonstrated between the results of prostacyclin infusion and those of Praxilene.