Identification of insertion mutations in HIV-1 reverse transcriptase causing multiple drug resistance to nucleoside analogue reverse transcriptase inhibitors. - Concepedia

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Identification of insertion mutations in HIV-1 reverse transcriptase causing multiple drug resistance to nucleoside analogue reverse transcriptase inhibitors.

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References

1999

Year

Wataru Sugiura, Masamichi Matsuda, Zene Matsuda, Hanae Abumi, Aiko Okano, Tsuyoshi Oishi, Kenji Moriya, Yasuhiro Yamamoto, Katsuyuki Fukutake, J Mimaya,

Abstract

A 2-amino acid insertion between codons 69 and 70 of RT was detected in 4 of 348 (1.1%) Japanese hemophiliacs and was found to be associated with multiple drug resistance to nucleoside analogue RT inhibitors.