PubMed · 1975 · 22 citations · 0 references
MedicineEndocrinologyPharmacologyHormone BiochemistryNeuroendocrinologyReproductive EndocrinologyEndocrine PharmacologyGrowth HormoneHypothalamic-pituitary RegulationPituitary Gland FunctionPituitary Hormone RegulationPituitary HormonesAnterior Pituitary Hormone SecretionBromocriptine TreatmentCortisol MetabolismFatty AcidsGrowth Hormone FunctionHypothalamic Regulation Of ProlactinPituitary Hormone PharmacologyPituitary Peptide Hormones
CB-154 was administered to six healthy subjects in three different single doses - 1 mg, 2,5 mg, and 3 mg. Growth hormone, prolactin, follicle stimulating hormone, luteinizing hormone, cortisol, blood sugar and free fatty acids were determined. 2.5 and 3 mg doses of CB-154 induced a significant rise in growth hormone and free fatty acids, while prolactin decreased. In addition, CB-154 prevented the circadian fall of plasma cortisol. There were no changes in follicle stimulating hormone, luteinizing hormone or blood sugar levels.