PubMed · 1996 · 28 citations · 0 references
Life SciencesImmunologyInfectious DiseasesClinical ImmunologyImmunopathologyStem Cell TransplantationAnemiaCombined ImmunodeficiencyHematologic DisordersImmunocompromised Host InfectionsImmunodeficiency DisordersPrimary ImmunodeficiencyAcquired Immunodeficiency SyndromeInfection After TransplantationOpportunistic Infections In ImmunodeficiencyPost-transplant ImmunodeficiencyTransplant-associated InfectionsTransplant-associated Opportunistic Infections
An infant with severe combined immunodeficiency (SCID) is described, who presented with severe anaemia and hepatosplenomegaly due to disseminated Bacillus Calmette-Guérin (BCG) infection involving the bone marrow, liver and spleen. After BMT, huge splenic enlargement occurred, presumably due to proliferation of engrafted donor lymphocytes, leading to severe hypersplenism. Peripheral blood cell consumption was resolved by splenectomy, but gradual loss of the marrow graft followed.