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HLA and schizophrenia in Israel.
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1988
Year
HistocompatibilityClass IiHla ImmunogeneticsImmunologyGenetic EpidemiologyPathologyNeuropsychiatryMental HealthHla SystemHla-dr AntigensAutoimmune DiseasePsychiatryHuman Leukocyte AntigenClinical PsychiatryEncephalitisPsychotic DisorderSchizophreniaHla TypingBiological PsychiatryMedicinePsychopathology
Thirty-two Israeli Jewish schizophrenic patients were typed for Class I (HLA-A, B, C) and Class II (HLA-DR) antigens. A significant increase of HLA-A2 (P = 0.01) and A23 (P = 0.02) was found. None of the 10 HLA-DR antigens tested was associated with the disease. Study of eight families indicated that close linkage of the gene responsible for this disorder to the HLA system is unlikely.