PubMed · 1989 · 35 citations · 0 references
MedicinePharmacologyPharmacotherapyGastroenterologyGastrointestinal PharmacotherapyInflammationAnti-inflammatory PharmacologyGastric DiseasesGastrointestinal InfectionsGastrointestinal InflammationGastrointestinal PathologyPeptic Ulcer DiseaseCampylobacter InfectionCase-control Study DesignGastric Ulcer DiseaseHelicobacter Pylori InfectionMultifactorial CausationMultifactorial EtiologyNonsteroidal Anti-inflammatory Drug GastropathyNonsteroidal Anti-inflammatory Drug Pharmacology
Although Campylobacter pylori has recently been causally linked to active chronic gastritis and peptic ulcer disease, its relationship to nonsteroidal antiinflammatory drug (NSAID) associated gastritis is unclear. We performed a case-control study of 100 patients who had undergone gastritis biopsy. Blinded review of Giemsa stained slides demonstrated the presence of C. pylori in 32% of 19 NSAID treated cases with active chronic gastritis vs 3% of 36 controls with chronic gastritis not taking NSAID, and 69% of 45 "positive" controls with active chronic gastritis not taking NSAID (p less than 0.001). Our results suggest a possible multifactorial etiology of NSAID associated gastritis.