Copper-Mediated Aerobic Oxidative Synthesis of 3-Bromo-imidazo[1,2-<i>a</i>]pyridines with Pyridines and Enamides

Abstract

A conversion of pyridines and enamides for the synthesis of 3-bromo-imidazo[1,2-a]pyridines was developed by copper-mediated aerobic oxidative coupling in a one-pot manner. This procedure tolerates various functional groups and affords a series of 3-bromo-imidazo[1,2-a]pyridines under mild conditions.