ARKIVOC · 2003 · 22 citations · 0 references
Life SciencesMedicinal ChemistryPharmacologyDna RepairDrug DiscoveryMolecular PharmacologyDna Damage-induced ApoptosisDna Double-strand Break RepairDna Polymerase FunctionEnzyme InhibitionPolymerase Chain ReactionDna Repair PathwaysParp InhibitionParp Inhibitor SensitivityPoly Adp-ribose Polymerase InhibitorsPoly(adp-ribose) Polymerase ActivityPoly(adp-ribose) Polymerase InhibitionPoly(adp-ribose) Polymerase InhibitorsPoly(adp-ribose) Polymerase-mediated Repair
4-Quinazolinones modified with 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole or 2,2,6,6tetramethyl-1,2,3,6-tetrahydropyridine rings and their N-oxyl derivatives were synthesized and some of them evaluated for protecting activity against H 2 O 2 induced cell death on WRL-68 human liver cell line. Compounds 15a, 15c and 15d exhibited remarkably inhibitory effects on PARP enzyme in vitro.