Gene amplification and methotrexate resistance in cultured animal cells.

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

F W Alt, Rodney E. Kellems, Joseph R. Bertino et al. · Journal of Biological Chemistry · 1978 · 979 citations · Full text

Dihydrofolate Reductase Genes, Genetics, Biochemical Genetics +8

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

Geoffrey M. Wahl, Richard A. Padgett, George R. Stark · Journal of Biological Chemistry · 1979 · 483 citations · Full text

Gene Amplification, Genetics, Molecular Biology +22

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

June L. Biedler, Barbara A. Spengler · Science · 1976 · 401 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

Jack H. Nunberg, Randal J. Kaufman, Robert Schimke et al. · Proceedings of the National Academy of Sciences · 1978 · 394 citations · Full text

Single Chromosome, Cytogenetics, Genetics +19

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

Randal J. Kaufman, Peter C. Brown, Robert Schimke · Proceedings of the National Academy of Sciences · 1979 · 394 citations · Full text

Cytogenetics, Genetics, Genomic Mechanism +17