A coagulopathy of the owl monkey (Aotus trivirgatus) associated with high antithrombin III activity.

Abstract

The species-associated coagulopathy of the owl monkey (Aotus trivirgatus) was shown to be caused by a high level of circulating anticoagulant, antithrombin III, in approximately 4-6 times the activity in which the same anticoagulant is found in man or the rhesus monkey (Macaca mulatta). The survival of the owl monkey in the presence of this added biological risk is an interesting and enigmatic observation. Treatment with protamine, prednisone, or estradiol did not alter the activity of circulating anticoagulant.