ACS Sensors · 2016 · 119 citations · 61 references
Natural SciencesBiochemistryChemistryBiomedical ImagingBiomedical OpticsMolecular ImagingFluorescence ImagingFluorescence SpectroscopyMolecular Probe DevelopmentNear-infrared ImagingOptical BiosensingOptical SpectroscopyBiological ImagingExcitationFluorescence ProbesFluorescent ProbesMolecular Imaging ProbesNear-infrared Fluorescence ImagingNear-infrared ProbesStokes Shift
Two-photon excitable (850 nm) NIR fluorescent turn-on (702 nm) probe TP-NIR was synthesized for selective detection of cysteine (Cys). The probe itself shows is turned on by reaction with Cys in aqueous buffer. In addition, the probe displays greater selectivity for Cys over other thiols, including glutathione (GSH) and homocysteine (Hcy). Moreover, the large Stokes shift, NIR excitation, and NIR emission make this probe suitable for biological imaging.
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