Acute Vascular Lesions Produced by Selected Non-pressor Rental Cortical Extracts

Abstract

Pressor and non-pressor aqueous extracts were separated from normal and ischemic rabbit kidney cortex by column chromatography and injected into test animals. Five to 6 test animals injected with the non-pressor extract from ischemic kidney developed vascular injuries especially in small cerebral arteries. This finding suggests that a non-pressor substance capable of producing vascular injury independent of renin is present in ischemic kidney cortex.