Effect of sustained diuresis on the renal lesions of mice with Bence Jones protein-producing tumors.

Abstract

Abstract BALB/c mice with tumors producing Bence Jones protein develop typical lesions with tubular casts very similar to the myeloma kidney in man. We have studied the effects of sustained diuresis and dehydration on the kidneys of these animals. As cast formation was a function of tumor size (r = 0.60, P