Reduction of epithelial secretion in male rat distal colonic mucosa by bile acid receptor <scp>TGR</scp>5 agonist, <scp>INT</scp>‐777: role of submucosal neurons

Abstract

TGR5 activation inhibits basal and stimulated distal colonic secretion in rats by acting directly on epithelial cells and also inhibiting submucosal neurons. This could represent a counter-regulatory mechanism, at the submucosal level, of the known prosecretory effect of bile acids in the colon.