Myocardial ischemic post-conditioning attenuates ischemia reperfusion injury via PTEN/Akt signal pathway.

Abstract

We confirmed that ischemic post-conditioning protects the heart against reperfusion injury. It is important that we demonstrated that the cardioprotective effect of ischemic post-conditioning was involved in the inhibition of PTEN, activation of the PI3K/Akt pathway and reduction of the cardiomyocyte apoptosis.