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Effects of beta-casomorphin derivatives on gastrointestinal transit in mice.
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1990
Year
Cm DerivativesGastrointestinal PharmacologyGastroenterologyPharmacotherapyDigestive TractGastrointestinal Peptide HormoneMedicinal ChemistryBiochemistryD-amino Acid-substituted DerivativesBeta-casomorphin DerivativesNon-peptide LigandPharmacologyFunctional SelectivityNatural SciencesPhysiologyCentral Opiate ReceptorsNeuropeptide ReceptorMedicineDrug Discovery
Some D-amino acid-substituted derivatives of beta-casomorphin (CM) were found to exhibit a special affinity to central opiate receptors. Concerning their affinity to peripheral opiate receptors our knowledge is still limited. The results of our experiments indicate that CM derivatives interfere with peripheral opiate receptors and that there is a close connection with the affinity to different subtypes of this receptor.