Secretion of hyaluronic acid from synovial fibroblasts is enhanced by histamine: a newly observed metabolic effect of histamine.

Abstract

We obtained evidence for the presence of histamine H1 and H2 receptors in normal synovial fibroblasts. Histamine enhanced proliferation of these synovial fibroblasts and stimulated the release of hyaluronic acid from these tissues. The molecular weight of hyaluronic acid decreased with this stimulation. The release of lower molecular weight hyaluronic acid from the synovium by histamine may be an important factor in joint disease.