2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection

TLDR

The Banff Working Group reviewed literature on antibody‑mediated liver allograft rejection at three Banff conferences and continued discussion online. The primary goal was to introduce guidelines and consensus criteria for diagnosing liver allograft antibody‑mediated rejection and to provide a comprehensive update of all Banff Schema recommendations. To produce a single reference document, unchanged criteria from prior meetings were retained. New recommendations cover C4d tissue staining and interpretation, fibrosis staging, and findings related to immunosuppression minimization.

Abstract

The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), and 13th (Vancouver, British Columbia, Canada, October 5-10, 2015) meetings of the Banff Conference on Allograft Pathology. Discussion continued online. The primary goal was to introduce guidelines and consensus criteria for the diagnosis of liver allograft antibody-mediated rejection and provide a comprehensive update of all Banff Schema recommendations. Included are new recommendations for complement component 4d tissue staining and interpretation, staging liver allograft fibrosis, and findings related to immunosuppression minimization. In an effort to create a single reference document, previous unchanged criteria are also included.