Nephrotoxicity of Cyclosporine A and Amphotericin B-deoxycholate as continuous infusion in allogenic stem cell transplantation

Abstract

Amphotericin B deoxycholate in addition to CsA leads to a statistically significant but clinically tolerable worsening of renal function. Using a 24-hour infusion and strict salt repletion, amphotericin B can be administered safely as deoxycholate in bone marrow transplant patients in conjunction with CsA for proven or suspected fungal infections.