A Monoclonal Antibody to Surface Antigens on Microfilariae of Brugia malayi Reduces Microfilaremia in Infected Jirds

Abstract

A monoclonal antibody to surface antigens of Brugia malayi microfilariae promotes the adherence of peripheral blood cells to microfilariae in vitro and reduces microfilaremia in vivo. The antibody reacts with epitopes present on two stage-specific antigens with estimated molecular weights of 70,000 and 75,000 daltons.