Evaluation of a double-injection method for sequential measurement of cerebral blood flow with iodine-123-iodoamphetamine.

Abstract

The double-injection method for IMP is feasible for two sequential rCBF measurements in a single procedure and is applicable for acetazolamide challenge. Simple microsphere model analysis, as well as a two-compartment model analysis, provide reliable assessment for cerebrovascular reactivity despite the complex dynamics of IMP and are feasible for clinical application.