Evaluating New Antimalarial Drugs against Trophozoite Induced Plasmodium Cynomolgi Malaria in Rhesus Monkeys

Abstract

An antimalarial drug testing system is described which utilizes trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys. The schizonticidal activity of standard antimalarial drugs in this system is reported. The system accurately predicted antimalarial activity in man of 8 of 9 compounds selected for clinical trials.