CLONAZEPAM IN THE TREATMENT OF EPILEPSY

Abstract

Clonazepam, a benzodiazepine derivative, has been used in the treatment of 46 patients with epilepsy who have failed to respond to treatment with other anticonvulsants. Plasma levels of the drug have been measured. It is particularly effective in the treatment of myoclonic epilepsy and self-induced photogenic seizures, but also has a role in the therapy of refractory petit mal and temporal lobe epilepsy. The usual effective oral dose of the drug is 6 mg/day, which maintains a plasma level of about 25 to 30 ng/ml.