Publication | Closed Access
Non-H-2 antigens can induce high GVH mortality in adult recipients of normal cells.
21
Citations
0
References
1978
Year
Clinical ImmunologyHistocompatibilityHigh Gvh MortalityF1 RecipientsImmunologyPathologyImmune SystemImmunotherapyBone Marrow FailureStem Cell TransplantationHematologyBone MarrowGraft SurvivalCell TransplantationTransplantationAllergyMarrow TransplantationAutoimmune DiseaseNon-h-2 AntigensMinor HistocompatibilityAutoimmunityHumoral ImmunityNormal CellsMedicineViral ImmunityGraft Rejection
It is demonstrated that, under experimental conditions resembling those used for bone marrow grafting in man, disparity for minor histocompatibility antigens alone (i.e., antigens coded for by genes not included in the major histocompatibility complex) is in fact sufficient for the induction of severe lethal graft-versus-host disease in adult (DBA/2 X B10.D2)F1 recipients of normal B10.D2 myeloid and lymphoid cells.