Dose‐response analysis of the efJects of tetrahydrocannabinol in man

Abstract

Fifteen volunteers smoked marihuana cigarettes under controlled laboratory conditions on five occasions. The cigarettes were calibrated to deliver doses of 0, 6.25, 12.5, 25, and 50 εg per kilogram of Δ‐9‐tetrahydrocannabinol(THC). A randomized block, double‐blind design was used. It was found that motor and mental performance as well as stability of stance deteriorated in a linearly dose‐dependent fashion. Heart rate and corüunctioal redness increased with dose as did scores on sensation and mood questionnaires.