VEGF expression in dog mastocytoma.

Abstract

Tumor cells were positive for VEGF, and inflammatory cells were negative. VEGF expression was found in tumor cells as a heterogeneous positive reaction, with cytoplasmic pattern and moderate to strong in intensity. Arrangement of tumor cells was in clusters, in deepest part, close to the proliferation front. The dog died 5 month from the diagnosis, and our observation suggest that VEGF secretion by tumor cells correlates with unfavorable prognosis.