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High Pressure Liquid Chromatographic Determination of Toxins Associated with Paralytic Shellfish Poisoning
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1983
Year
EngineeringToxinologyEnvironmental ChemistryToxins AssociatedBioanalysisToxicologyAnalytical ChemistryToxicological AspectChromatographyBiochemistryPoisoningParalytic Shellfish PoisoningHplc ProcedureEcotoxicologyPharmacologyToxin AnalysisPeriodic AcidMicrobiologyEnvironmental ToxicologyMedicineDrug Analysis
A high pressure liquid chromatographic procedure is described for assay of toxins associated with paralytic shellfish poisoning (PSP). The method is applicable to saxitoxin, neosaxitoxin, gonyautoxins I through IV, and their sulfocarbamoyl derivatives. Toxins are separated on a bonded phase cyano column and detected by fluorescence following alkaline oxidation (NH+4 and periodic acid). The utility of the HPLC procedure for research and monitoring is discussed.