Response of Urethral Smooth Muscles to Pharmacological Agents. II. Noncholinergic, Nonadrenergic Agonists and Antagonists

Abstract

No AccessJournal of Urology1 Nov 1983Response of Urethral Smooth Muscles to Pharmacological Agents. II. Noncholinergic, Nonadrenergic Agonists and Antagonists Amr Abdel-Hakim, Magdy Hassouna, Francis Rioux, Serge St-Pierre, Mohamed Abdel-Rahman, Cesar Galeano, and Mostafa Elhilali Amr Abdel-HakimAmr Abdel-Hakim Current address: Urology Department, Cairo University, Cairo, Egypt. More articles by this author , Magdy HassounaMagdy Hassouna More articles by this author , Francis RiouxFrancis Rioux More articles by this author , Serge St-PierreSerge St-Pierre More articles by this author , Mohamed Abdel-RahmanMohamed Abdel-Rahman Current address: Urology Department, Alexandria University, Alexandria, Egypt. More articles by this author , Cesar GaleanoCesar Galeano More articles by this author , and Mostafa ElhilaliMostafa Elhilali More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)51613-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We studied the effects of a variety of noncholinergic, nonadrenergic agents on the smooth muscles of the cat urethra. Prostaglandin F2α contracted both urethral muscle layers to a similar extent. Prostaglandin E2 contracted the longitudinal and relaxed the circular muscle layers. The effects of the prostaglandins seem to be directly myogenic since cholinergic and adrenergic blockers and tetrodotoxin did not affect them. Bradykinin and substance P contracted both urethral muscle layers. Other tested agonists (neurotensin, vasoactive intestinal peptide, cyclic 3,5 adenosine monophosphate, adenosine diphosphate sodium, cyclic 3,5 guanosine monophosphate sodium, bombesin) had no effect on the cat urethral smooth muscles. © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySekido N, Kida J, Mashimo H, Wakamatsu D, Okada H and Matsuya H (2018) Promising Effects of a Novel EP2 and EP3 Receptor Dual Agonist, ONO-8055, on Neurogenic Underactive Bladder in a Rat Lumbar Canal Stenosis ModelJournal of Urology, VOL. 196, NO. 2, (609-616), Online publication date: 1-Aug-2016.Christ G, Bushman W and Fraser M (2009) Impact of Diabetes and Obesity on the Prostate and Urethra: Implications to Improved Bladder Dysfunction Understanding and TreatmentJournal of Urology, VOL. 182, NO. 6S, (S38-S44), Online publication date: 1-Dec-2009.Zuraw B, Sugimoto S, Parsons C, Hugli T, Lotz M and Koziol J (2018) Activation of Urinary Kallikrein in Patients with Interstitial CystitisJournal of Urology, VOL. 152, NO. 3, (874-878), Online publication date: 1-Sep-1994.Sjögren C, Andersson K and Mattiasson A (2018) Effects of Vasoactive Intestinal Polypeptide on Isolated Urethral and Urinary Bladder Smooth Muscle from Rabbit and ManJournal of Urology, VOL. 133, NO. 1, (136-140), Online publication date: 1-Jan-1985. Volume 130Issue 5November 1983Page: 988-991 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Amr Abdel-Hakim Current address: Urology Department, Cairo University, Cairo, Egypt. More articles by this author Magdy Hassouna More articles by this author Francis Rioux More articles by this author Serge St-Pierre More articles by this author Mohamed Abdel-Rahman Current address: Urology Department, Alexandria University, Alexandria, Egypt. More articles by this author Cesar Galeano More articles by this author Mostafa Elhilali More articles by this author Expand All Advertisement Loading ...