Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus.

Abstract

The gene expression of CCK-A receptor on the smooth muscle of the gallbladder may decrease more significantly in patients with gallstone and diabetes mellitus than in those with gallstone only; this result is consistent with the decreased motility. Thus the lowered expression of CCK-A receptor is probably the cause of hypomotility in patients with gallstones and diabetes mellitus.