Flutriciclamide (¹⁸F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein

Abstract

We report for the first time, to our knowledge, the kinetic properties of the novel third-generation TSPO PET ligand ¹⁸F-GE180 in humans: 2TCM4k is the optimal method to quantify the brain uptake, 90 min is the optimal scan length, and the Logan approach could be used to generate parametric maps. Although these control subjects have shown relatively low V_T, the methodology presented here forms the basis for quantification for future PET studies using ¹⁸F-GE180 in different pathologies.