Murine Congenital Polycystic Kidney Disease: A Model for Studying Development of Cystic Disease

Abstract

No AccessJournal of Urology1 Mar 1982Murine Congenital Polycystic Kidney Disease: A Model for Studying Development of Cystic Disease Glenn M. Preminger, M.D. William E. Koch, Ph.D. Floyd A. Fried, M.D. Eleanor McFarland, Edwin D. Murphy, andM.D. James Mandell Glenn M. PremingerGlenn M. Preminger More articles by this author , William E. KochWilliam E. Koch More articles by this author , Floyd A. FriedFloyd A. Fried More articles by this author , Eleanor McFarlandEleanor McFarland More articles by this author , Edwin D. MurphyEdwin D. Murphy More articles by this author , and James MandellJames Mandell More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)53911-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The genetic, clinical and pathologic characteristics of murine congenital polycystic kidney disease (CPK) have been examined in mutant mice highly congenic with C57BL/6J inbred strains. This CPK defect appears to resemble closely human Infantile Polycystic Kidney Disease in its pattern of inheritance, clinical course, and appearance of the kidney in the severely affected animal. Histologic studies of early postnatal animals suggest that cystic alterations may occur first in the proximal tubules and secondarily affect the collecting ducts. The CPK mouse mutant should prove useful in further investigations into the early morphologic alterations and progression of cystic disease. © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byKoumegawa J, Nagano N, Arai H, Wada M, Kusaka M and Takahashi H (2018) Anemia in New Congenital Adult Type Polycystic Kidney MiceJournal of Urology, VOL. 146, NO. 6, (1645-1649), Online publication date: 1-Dec-1991.Horton C, Davisson M, Jacobs J, Bernstein G, Retik A and Mandell J (2018) Congenital Progressive Hydronephrosis in Mice: A New Recessive MutationJournal of Urology, VOL. 140, NO. 5 Part 2, (1310-1315), Online publication date: 1-Nov-1988.Takahashi H, Ueyama Y, Hibino T, Kuwahara Y, Suzuki S, Hioki K and Tamaoki N (2018) A New Mouse Model of Genetically Transmitted Polycystic Kidney DiseaseJournal of Urology, VOL. 135, NO. 6, (1280-1283), Online publication date: 1-Jun-1986.Fry J, Koch W, Jennette J, Mcfarland E, Fried F and Mandell J (2018) A Genetically Determined Murine Model of Infantile Polycystic Kidney DiseaseJournal of Urology, VOL. 134, NO. 4, (828-833), Online publication date: 1-Oct-1985.Nidess R, Koch W, Fried F, McFarland E and Mandell J (2018) Development of the Embryonic Murine Kidney in Normal and Congenital Polycystic Kidney Disease: Characterization of a Proximal Tubular Degenerative Process as the First Observable Light Microscopic DefectJournal of Urology, VOL. 131, NO. 1, (156-162), Online publication date: 1-Jan-1984. Volume 127Issue 3March 1982Page: 556-560 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Glenn M. Preminger More articles by this author William E. Koch More articles by this author Floyd A. Fried More articles by this author Eleanor McFarland More articles by this author Edwin D. Murphy More articles by this author James Mandell More articles by this author Expand All Advertisement PDF downloadLoading ...