Publication | Closed Access
Renin-induced massive proteinuria in man.
37
Citations
0
References
1979
Year
Glomerular DiseaseHypertensionRenal PathologyRenal InflammationPathologyGlomerulonephritisRenal FunctionElectron MicroscopyIga GlomerulonephritisAcute Kidney InjuryChronic Kidney DiseaseRenal PharmacologyHemodialysisSodium HomeostasisRenal PathophysiologyRenin-induced Massive ProteinuriaEnd-stage Renal DiseaseUrologyRenal DiseaseRenovascular HypertensionMalignant HypertensionMedicineNephrologyKidney Research
A 30 year old man developed renovascular hypertension and extreme elevation of plasma renin activity. Daily proteinuria ranged from 13 to 31 g. There were no criteria for the diagnosis of malignant hypertension. A primary glomerulopathy was excluded by a basically normal renal biopsy from the unprotected kidney. On electron microscopy the epithelial cell foot processes were not fused, thus ruling out simultaneous lipoid nephrosis. The source of renin was removed by means of a left nephrectomy. Following the procedure the patient became normotensive, the renin values normalized and the proteinuria disappeared. The results suggest that renin can cause significant proteinuria in man.