Hemostatic Defects in Dysproteinemias

Abstract

Bt1 HERBERT A. PE aNs, MALCOLM R. MACKENZIE AND H. HUGH FUDENBERG T HE ASSOCIATION OF HIGH CONCENTRATIONS of certain paraproteins and abnormal bleeding is well recognized, but the mechanism of defective hemostasis is uncertain. Numerous publications, generally restricted to single case reports or to small series of patients, describe a bewildering inconsistency of abnormal findings, some of which appear to correlate with bleeding while others do not. Possible explanations for these discrepancies include