Forty-four Months' Experience in the Treatment of Leprosy with Clofazimine (Lamprene (Geigy))

Abstract

The author's experience in trea ting 123 patients with c10fazimine is reported. Long-standing corticosteroid-dependent erythema nodosum leprosum (ENL) was adequately controlled after an average of 7 months of treatment with clofazimine. After an average of 16 months, recurrence of ENL was negligible. Early cases of ENL were easier to control. Patients with neuritis, and those with tuberculoid and borderline reactions and suspected dapsone resistance also responded favourably to clofazimine. A controlled trial over 2Y 2 years indicated that while the addition of c10fazimine to dapsone in the treatment of patients with lepromatous leprosy did not hasten bacillary clearance, the incidence of reactions was considerably decreased .